Silicone Rubber Septum: Solvent Compatibility in Pharmaceutical Analysis

Black Rubber septa are molded from a higher density rubber compound compared to the standard red rubber. This septum has characteristics similar to the gray butyl stopper. The Black rubber septum is an economical choice for applications where reduced levels of vapor penetration are desired. Temperature stability chart Min. temp °C Max. temp

Sep 5, 2022 · Volatile organic compounds are of great importance for communication within biological systems. For the experimental investigation of the functions of volatiles, methods for experimental manipulation are needed. Based on scent-release methods from pheromone research, we describe a simple and cheap method for scent manipulation using silicone rubber (i.e. a silicone septum). Volatile compounds

of rubber offer better resistance to acetone, certain other ketones, and some esters. The fluorosilicone polymer can be blended with other silicone polymers to obtain resistance intermediate between the two types. 2. The higher the aromatic or phenyl content of oils and fuels, the greater is their effect on most types of silicone rubber

PTFE-fused septa are suitable to overcome the degradation, which happens due to prolonged high temperatures, commonly observed in silicone rubber septa. The degradation results in baseline drift and additional peaks. It is generally fixed with the PTFE face towards the column packing.

Silicone rubber has excellent chemical compatibility with a wide range of materials, often providing and advantage over other materials with similar elastomeric properties. In particular, silicone displays outstanding chemical compatibility with water, aqueous and most chemically polar substances.

Nov 8, 2017 · solution of drug product are based on compatibility studies; however such compatibility studies as described in the pharmaceutical development report did not discuss potential leachables. Explain why such control strategies applied for Drug Product (DP) manufacturing is adequate and why similar holding and flushing strategies as

Black rubber septa are molded from a higher density rubber compound compared to the standard red rubber. This septum has characteristics similar to the gray butyl stopper with a slightly smaller temperature range of –20 t0 100°C. The Black Rubber septum is an economical choice for applications where reduced levels of vapor penetration are

Nalgene Tubing. Nalgene tubing products include a comprehensive range of premium lab tubing in a variety of sizes and materials. Choose polyvinylchloride (PVC), silicone (SI) or polyurethane (PUR) for applications where flexible tubing is required. Choose linear low density polyethylene (LLDPE) or one of our fluoropolymer (FEP or PFA

Choosing the right septa and closures for your analysis is critical to ensure chemical compatibility with your sample and solvents and protect sample integrity and prevent contamination. Screw and snap caps are usually made of plastic, mostly polypropylene (PP) or polyethylene (PE), whereas seals for crimp-top vials are made from aluminum.

Add to Compare. Kinesis – Item # EW-98706-03. Choose the right septum for optimal performance and results. Various materials, thicknesses and hardnessess to suit your application. Pre-slit septa prevent a vacuum forming inside the vial. Natural PTFE/clear silicone, 15 mm dia. MORE +.

Jan 2, 2006 · Figure 3 - Typical mass chromatogram of volatile residue in hexane caused by PTFE/silicone septa: a) hexane extract of a piece of septum; b) vial septum was punctured once by a syringe to sample 1 μL hexane for GC analysis; c) hexane in the last vial was reanalyzed after 3 days; and d) analyzed immediately after 100 μL hexane was added from one vial to another (the septum was punctured 10

Silicone rubber septa. High quality, silicone rubber laminated to PTFE. Use when excellent resealing qualities are a must. Septum resists coring and is recommended when multiple injections are required. Preferred septa for use in liquid chromatography applications.

PTFE chemical resistance until punctured, then the septum will have the chemical compatibility of silicone Working temperature range from -40 ˚C to 200 ˚C Pre-slit PTFE/Silicone Provides adequate venting to prevent vacuum formation in sample vial, delivering excellent sample-draw reproducibility Eliminates coring from bottom draw needles

components separate and limits excessive migration of solvents or gases between chambers. Additional functional requirements depend on the intended use of the individual packaging/delivery system. In prefilled syringes and cartridges, and in pen, jet, and related injectors, the elastomeric closure (i.e., the

Sep 1, 2018 · In our studies the use of 2-propanol as extraction solvent has proved to be suitable for rubber stopper quality analysis with respect to its extractables profile. Also, protein-containing drugs as mere aqueous systems must be critically evaluated because of the use of surfactants like polysorbates that can influence the migration behaviour of